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Community-directed therapy with ivermectin (CDTI), for the control of onchocerciasis, was launched in Uganda in 1997. In East Africa, as in other endemic areas, the refusal to take the drug reduces treatment protection and subsequently poses a severe risk to attempts to eradicate onchocerciasis as a disease of public-health importance. A few of the main signs related to these parasite infections embody diarrhea, constipation, nausea, abdominal pain, bloating, dehydration, weakness, low energy, and joint ache. Typical symptoms include colicky stomach ache, vomiting, diminished power and passing stool consisting primarily of blood and mucus -- which can resemble pink jelly. Fifteen sheep closely infested with totally different ectoparasites have been randomly divided into 3 equal groups (groups B, C and D) consisting of 5 sheep in every. The research has been carried out from February to March 2005 on 20 sheep (infested and non infested with ectoparasites) of each sexes aged upto three to 4 years on the animal home of Veterinary Clinic, Bangladesh Agricultural University, Mymensingh to check the efficacy of ivermectin pour on (Ivermec® Pour on, Ethical Drugs Ltd., Dhaka, Bangladesh) towards ectoparasites and its effect on certain haematological (Hb, TEC and PCV) parameters and body weight gain. The result of the 14 day experment showed that therapen-tic impact ofⅢgroup was finest and rising weight was the most effective remarkable(P 0.01) .